PREPARATIONS TO COMMIT A CRIME<BR> THE DUTCH APPROACH TO INCHOATE OFFENCES



Computational Modeling to Identify Drugs Targeting Metastatic Castration-Resistant Prostate Cancer Characterized by Heightened Glycolysis

Metastatic castration-resistant prostate cancer (mCRPC) remains a deadly disease due to a lack of efficacious treatments.The reprogramming of cancer metabolism toward elevated glycolysis is a hallmark of mCRPC.Our goal is to identify therapeutics specifically associated with high glycolysis.Here, we established a computational framework to identify

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Microtubules oppose cortical actomyosin-driven membrane ingression during C. elegans meiosis I polar body extrusion.

During C.elegans oocyte meiosis I cytokinesis and polar body extrusion, cortical actomyosin is locally remodeled to assemble a contractile ring that forms within and remains part of a much larger and actively contractile cortical actomyosin network.This network both mediates contractile ring dynamics and generates shallow ingressions throughout the

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